Dr. Alfredo A. Santillan-Gomez is a board certified general surgeon with a specialty in surgical oncology. He is fully devoted to the oncology and endocrine surgical fields.

Dr. Santillan received his medical doctorate with honors from the Institute of Technology, Monterrey, N.L., Mexico and obtained a master’s degree in public health at Harvard University. He completed his residency in general surgery at Texas Tech University. As a senior surgery resident, he was awarded the Allando Ballantyne fellowship in head and neck surgery at The University of Texas MD Anderson Cancer Center.

He received advanced training in surgical oncology at Moffitt Cancer and Research Center, University of South Florida, in Tampa. Prior to joining Texas Oncology, Dr. Santillan-Gomez served for seven years as an associate professor in the division of surgical oncology and endocrine surgery at The University of Texas Health at San Antonio and is currently an adjunct professor of the division of epidemiology and biostatistics at The University of Texas Health Science Center at San Antonio.

Dr. Santillan’s areas of expertise include oncologic and endocrine surgery with emphasis on surgical diseases of the breast, thyroid, parathyroid, adrenal, colon, melanoma, pancreas and sarcoma. He has practiced in San Antonio since 2009 and is recognized as a leader in cancer and endocrine surgery with extensive surgical experience.

He is a Hidden Scar trained surgeon on advanced minimally invasive and minimal access surgical approaches that deliver optimal clinical and aesthetic outcomes for patients with breast cancer.

He is one of the few high thyroid volume surgeons in South Texas, according to the American Thyroid Association guidelines, with more than 100 thyroid surgeries per year.

Background & Education

  • Fellowship in Surgical Oncology
    Moffitt Cancer Center, University of South Florida, Tampa, FL
  • Fellowship in Head and Neck Oncology
    Allando Ballantyne Fellowship in Head and Neck Surgery at M.D. Anderson Cancer Center, University of Texas, Houston, TX
  • Residency in General Surgery
    Texas Tech University Health Sciences Center, El Paso, TX
  • Master of Public Health, Quantitative Methods
    Harvard T.H. Chan School of Public Health, Boston, MA
  • Medical Doctorate
    Monterrey Institute of Technology and Higher Education, Monterrey, N.L., México

Surgical Locations

  • Methodist Hospital
  • St. Lukes Baptist Hospital
  • CHRISTUS Santa Rosa Hospital - Medical Center
  • CHRISTUS Santa Rosa Hospital - Westover Hills
  • Methodist Stone Oak Hospital
  • Methodist Specialty and Transplant Hospital
  • Methodist Landmark
  • Methodist Ambulatory Surgery Medical Center
  • North Central Baptist at Stone Oak

Surgical Procedures


Internal Mammary Lymph Node Biopsy During Free-Flap Breast Reconstruction: Optimizing Adjuvant Breast Cancer Treatment Through Comprehensive Staging
Annals of Surgical Oncology, 2018

Phyllodes Tumors: Race-Related Differences
Journal of the American College of Surgeons, 2011

Feasibility of Sentinel Lymph Node Biopsy Through an Inframammary Incision for a Nipple-Sparing Mastectomy
Annals of Surgical Oncology, 2008

Phosphorylated Insulin Like Growth Factor-I Receptor Expression and Its Clinico-Pathological Significance in Histologic Subtypes of Human Thyroid Cancer
Experimental Biology and Medicine / Society for Experimental Biology and Medicine, 2009

Pathology Review of Thin Melanoma and Melanoma In Situ in a Multidisciplinary Melanoma Clinic: Impact on Treatment Decisions
Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 2010

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